Ortho-eugenol exhibits anti-nociceptive and anti-inflammatory activities
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- 作者：Diogo V. Fonsê ; caa ; b ; Paula R.R. Salgadob ; Humberto de C. Aragã ; o Netoa ; b ; Adriana M.F.O. Golziob ; Marcelo R.D. Caldas Filhoa ; b ; Cynthia G.F. Meloa ; b ; Fagner C. Leitea ; c ; Marcia R. Piuvezama ; c ; Liana Clé ; bia de Morais Pordeusb ; José ; M. Barbosa Filhoa ; Reinaldo N. Almeidaa ; b ; reinaldoan@uol.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ortho-eugenol ; Anti-nociception ; Inflammation ; NF-kB ; p38
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：402-408
- 全文大小：702 K
文摘
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Ortho-eugenol does not alter motor coordination in mice.
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Ortho-eugenol has antinociceptive activity mediated by the adrenergic system.
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Ortho-eugenol reduces levels of IL-1β and TNF-α proinflammatory cytokines.
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Ortho-eugenol exhibits anti-inflammatory effects by virtue of NF-kB-p and p-p38 suppression.