Generation of switched memory B cells in response to vaccination in Down syndrome children and their siblings
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- 作者：Diletta Valentini<sup>asup> ; Valentina Marcellini<sup>bsup> ; Simona Bianchi<sup>asup> ; Alberto Villani<sup>asup> ; Marzia Facchini<sup>csup> ; Isabella Donatelli<sup>csup> ; Maria Rita Castrucci<sup>csup> ; Emiliano Marasco<sup>bsup> ; Chiara Farroni<sup>bsup> ; Rita Carsetti<sup>bsup><sup> ; sup><sup>dsup><sup> ; sup><sup>rita.carsetti@opbg.net" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Down syndrome ; Vaccination ; Switched memory B cells ; Antibodies ; Respiratory infections
- 刊名：Vaccine
- 出版年：2015
- 出版时间：27 November 2015
- 年：2015
- 卷：33
- 期：48
- 页码：6689-6696
- 全文大小：592 K
文摘
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Down syndrome is associated to a reduction of switched memory B cells.
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Impaired production of specific switched memory B cells after primary vaccination.
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Increase of specific switched memory B cells after booster vaccination.
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Normal serum antibodies response to vaccination.
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Tailored vaccination protocols are needed for Down syndrome individuals.