Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: The InCHIANTI study

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• 作者：Marcello Maggio ; Gian Paolo Ceda ; Fulvio Lauretani ; Stefania B ; inelli ; Elisabetta Dall’ ; Aglio ; Jack M. Guralnik ; Giuseppe Paolisso ; Richard D. Semba ; Antonio Nouvenne ; Loris Borghi ; Graziano Cer
• 关键词：Aging ; Total IGF-1 ; Selenium
• 刊名：Clinical Nutrition
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：29
• 期：5
• 页码：674-677
• 全文大小：176 K

文摘

Summary

Background & aims

Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown.

Methods

Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy.

Results

Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2) ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β ± SE: 43.76 ± 11.2, p = 0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β ± SE: 36.7 ± 12.2, p = 0.003). The association was still significant when IL-6 was introduced in the model (β ± SE: 40.1 ± 12.0, p = 0.0008).

Conclusions

We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.