Trypanosoma cruzi: Genome characterization of phosphatidylinositol kinase gene family (PIK and PIK-related) and identification of a novel PIK gene
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- 作者：Priscila Oliveiraa ; 1 ; Fabio Mitsuo Limaa ; 1 ; Mario Costa Cruza ; 1 ; Renata Carmona Ferreiraa ; Alejandro Sanchez-Floresb ; Esteban Maurí ; cio Corderoa ; Danielle Rodrigues Corteza ; É ; den Ramalho Ferreiraa ; Marcelo Ribeiro da Silva Brionesa ; Renato Arruda Mortaraa ; José ; Franco da Silveiraa ; Diana Bahiaa ; c ; dianabahia@hotmail.com" class="auth_mail
- 关键词：Phosphatidylinositol kinases ; Trypanosoma cruzi ; Target of rapamycin ; FYVE domain ; FYVE-PIK ; PIK
- 刊名：Infection, Genetics and Evolution
- 出版年：July 2014
- 年：2014
- 卷：25
- 期：Complete
- 页码：157-165
- 全文大小：2261 K
文摘
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There is an extensive PIK polymorphism at genomic localization level in T. cruzi.
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FYVE-PIK is a trypanosomatid PIK gene that might be acquired by horizontal transfer.
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The localization of TOR proteins within Trypanosoma genus is different.
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Polymorphism may be considered in designing drugs and vaccines for Chagas’ disease.