Monocytosis has adverse prognostic significance and impacts survival in patients with T-cell lymphomas

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• 作者：Alessia Bari^a ; Tamar Tadmor^b ; Stefano Sacchi^a ; ^{stefano.sacchi@unimore.it} ; Luigi Marcheselli^a ; Eliana Valentina Liardo^a ; Samantha Pozzi^a ; Stefano Luminari^a ; Luca Baldini^c ; Sandra Marmiroli^d ; Massimo Federico^a ; Aaron Polliack^e
• 关键词：Monocytosis ; Non-Hodgkin lymphoma ; Peripheral T-cell lymphoma ; Prognostic value ; Overall survival
• 刊名：Leukemia Research
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：37
• 期：6
• 页码：619-623
• 全文大小：305 K

文摘

In this retrospective study we evaluated the prognostic impact of peripheral blood monocytosis in patients with T-cell non Hodgkin lymphomas with ¡°aggressive-typically nodal presentation¡±. In this dataset monocytes >0.8 ¡Á 10⁹/L had a strong and statistically significant negative impact on overall survival (OS).

In univariate analysis several parameters, including age >60 years, advanced stage, bone marrow involvement, ECOG PS >1, high LDH level, monocytes >0.8 ¡Á 10⁹/L, hemoglobin < 120 g/L, albumin < 35 g/L) had a negative influence on outcome, but in multivariate analysis, monocytosis alone had a stronger association with poor OS.