Struthanthus vulgaris ointment prevents an over expression of inflammatory response and accelerates the cutaneous wound healing

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• 作者：Luciane Souza dos Santos Gramma^a ; Franciane Martins Marques^a ; Cá ; tia Vittorazzi^a ; Thiago Antô ; nio Moretti de Andrade^b ; Marco Andrey Cipriani Frade^c ; Tadeu Uggere de Andrade^a ; Denise Coutinho Endringer^a ; Rodrigo Scherer^a ; Marcio Fronza^a ; ^{marcio.fronza@uvv.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Wound healing ; Inflammation ; Inflammatory infiltrate ; Cytokines ; Medicinal plants ; Struthanthus vulgaris
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：22 August 2016
• 年：2016
• 卷：190
• 期：Complete
• 页码：319-327
• 全文大小：6783 K

文摘

Struthanthus vulgaris (Vell.) Mart. (Loranthaceae) has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and to treat various skin disorders, including wounds.

Aims of the study

To investigated the influence of 5% Struthanthus vulgaris ointment during cutaneous wound healing in rats.

Materials and methods

Twenty Wistar rats were used in each group according the daily treatment, S. vulgaris 5% ointment (SV 5%) and vehicle control groups. Four full thicknesses wounds were punched in back side skin of each animal, and five animals were sacrificed after 2, 7, 14 and 21 days after surgery for histological, immunological and biochemical analysis.

Results

A significant wound closured area in the S. vulgaris 5% group of about 38% and 35% as compared to 19% and 21% in the control group was observed after 2 and 5 days, respectively. Histological and biochemical analysis of the skin biopsies showed that S. vulgaris treated wounds exhibited increased granulation tissue and regulated the inflammatory response by modulating the release of pro and anti-inflammatory cytokines like IL-1α, TNF-α and IL-10, nitric oxide and, growth factors like TGF-β. Moreover, S. vulgaris showed a marked and robust increase in the deposition and organization of collagen fibers in the wounds, and improve the quality of the scar tissue.

Conclusions

Altogether these data revealed that S. vulgaris seems to prevent an over expression of inflammation and accelerates wound epithelialization and might be beneficial for treating healing disorders.