Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

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• 作者：Mohamed Abdulkadir^a ; ^b ; ^{abdulkadir@dls.rutgers.edu" class="auth_mail" title="E-mail the corresponding author} ; Jay A. Tischfield^a ; Robert A. King^c ; Thomas V. Fernandez^c ; Lawrence W. Brown^d ; Keun-Ah Cheon^e ; Barbara J. Coffey^f ; ^g ; Sebastian F.T.M. de Bruijn^h ; Lonneke Elzermanⁱ ; Blanca Garcia-Delgar^j ; Donald L. Gilbert^k ; Dorothy E. Grice^f ; Julie Hagstrø ; m^l ; Tammy Hedderly^m ; Isobel Heymanⁿ ; Hyun Ju Hong^o ; Chaim Huyser^p ; Laura Ibanez-Gomez^f ; ^g ; Young Key Kim^q ; Young-Shin Kim^r ; Yun-Joo Koh^s ; Sodahm Kook^t ; Samuel Kuperman^u ; Andreas Lamerz^v ; Bennett Leventhal^r ; Andrea G. Ludolph^w ; ^&dagger ; ; Marcos Madruga-Garrido^x ; Athanasios Marasⁱ ; ^y ; Marieke D. Messchendorp^b ; Pablo Mir^z ; Astrid Morer^aa ; ^ab ; Alexander Mü ; nchau^ac ; Tara L. Murphyⁿ ; Thaï ; ra J.C. Openneer^b ; Kerstin J. Plessen^l ; Judith J.G. Rath^h ; Veit Roessner^ad ; Odette Frü ; ndt^ae ; Eun-Young Shin^e ; Deborah A. Sival^af ; Dong-Ho Song^e ; Jungeun Song^ag ; Anne-Marie Stolte^ah ; Jennifer Tü ; bing^ac ; Els van den Ban^ai ; Frank Visscher^aj ; Sina Wanderer^ad ; Martin Woods^m ; Samuel H. Zinner^ak ; Matthew W. State^r
• 关键词：Attention-deficit hyperactivity disorder ; Delivery ; Obsessive-compulsive disorder ; Pregnancy ; Prenatal ; Tourette syndrome
• 刊名：Journal of Psychiatric Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：82
• 期：Complete
• 页码：126-135
• 全文大小：309 K

文摘

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.