Toxicity and cosmesis following partial breast irradiation consisting of?40?Gy in 10 daily fractions
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- 作者：Marco Trovo ; Mario Roncadin ; Jerry Polesel ; Erica Piccoli ; Mario Mileto ; Elvia Micheli ; Tiziana Perin ; Antonino Carbone ; Samuele Massarut ; Mauro G. Trovo
- 关键词：Breast cancer ; Partial breast irradiation ; Toxicity ; Cosmesis ; Hypofractionation
- 刊名：The Breast
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：22
- 期：5
- 页码：744-747
- 全文大小：175 K
文摘
Purpose
To assess the toxicity and cosmetic results in breast cancer patients undergoing adjuvant partial breast irradiation (PBI) to a total dose of 40?Gy in 10 daily fractions (4?Gy/fraction).Methods and materials
Patients affected by early-stage breast cancer were enrolled in this phase II trial. Patients had to be 60 years old and treated with breast conservative surgery for early stage (pT1-T2 pN0-N1a) invasive ductal carcinoma.
Results
77 patients were enrolled. Median follow-up was 18 months. The proposed schedule was well tolerated. One patient reported Grade 3 pain at the site of irradiation. Four (5 % ) patients experience Grade 2 erythema. Late Grade 2 and 1 fibrosis was observed in 3 (4 % ) and 14 (18 % ) patients, respectively. Cosmesis was judged ¡°good/excellent¡± and ¡°poor¡± in 75 (97 % ) and in 2 (3 % ) patients, respectively.
Conclusions
40?Gy in 10 daily fractions, 4?Gy/fraction, is a well tolerated regimen to deliver PBI.