Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy

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• 作者：Wagner L. Prado Ph.D.^a ; ^{wagner.prado@pq.cnpq.br"" rel=""nofollow} ; Lila M. Oyama Ph.D.^a ; ^b ; Mara C. Lofrano-Prado M.S.^a ; Aline de Piano M.S.^a ; Sé ; rgio G. Stella Ph.D.^a ; Clá ; udia M.O. Nascimento Ph.D.^a ; June Carnier M.S.^a ; Danielle A. Caranti Ph.D.^a ; Lian Tock M.D.^a ; Sé ; rgio Tufik Ph.D.^c ; Marco T&#xfa ; lio de Mello Ph.D.^a ; ^c ; Ana R. Dâ ; maso Ph.D.^a ; ^b
• 关键词：Obesity ; Exercise ; Ghrelin ; Leptin ; Neuropeptides ; Food intake
• 刊名：Journal of Adolescent Health
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：49
• 期：3
• 页码：300-305
• 全文大小：492 K

文摘

Objective

The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein [AgRP], neuropeptide Y [NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone [α-MSH]), in obese adolescents.

Methods

A total of 88 adolescents (38 boys and 50 girls), including 62 obese and 26 normal-weight, aged 15–19 years were recruited. Obese adolescents were submitted to a 24-week multidisciplinary therapy. AgRP, NPY, melanin-concentrating hormone, leptin, insulin, glucose, α-MSH, total ghrelin, and food intake were measured at three stages (at baseline, after 12 weeks, and after 24 weeks).

Results

At baseline, obese adolescents showed hyperleptinemia (circulating leptin levels, which were, in boys and girls, 40 and 35 times higher than in normal-weight subjects, respectively). After 24 weeks, these values decreased in all obese patients. Our results showed no differences in ghrelin levels between obese and normal-weight adolescents, in both genders. However, obese boys reduced their plasma ghrelin concentration after 24 weeks of therapy (p < .05). The multidisciplinary therapy decreased NPY and AgRP values and increased α-MSH; simultaneously with these changes there was a decrease in total food intake after 24 weeks of therapy.

Conclusions

We can conclude that the multidisciplinary therapy was efficient to modulate neurohormonal control of food intake in obese adolescents.