In situ monitoring of myenteric neuron activity using acetylcholinesterase-modified AlGaN/GaN solution-gate field-effect transistors
详细信息 查看全文
- 作者：Gesche Mareike Mü ; ntzea ; gesche.m.muentze@exp1.physik.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author ; Ervice Pouokamb ; Julia Steidleb ; Wladimir Schä ; fera ; Alexander Sassea ; Kai Rö ; tha ; Martin Dienerb ; Martin Eickhoffa
- 关键词：EnFET ; Acetylcholineseterase ; AlGaN/GaN HEMT ; Neuron activity ; Bioelectronics ; Cell-transistor hybrid
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：1048-1054
- 全文大小：835 K
文摘
- •
Reproducible and stable acetylcholinesterase-modified FETs (AcFETs) are realized.
- •
Covalently immobilized acetylcholinesterase is quantitatively analyzed.
- •
AlGaN/GaN FETs are a suitable platform for the comparative analysis of enzyme kinetics.
- •
AcFETs are used to monitor myenteric neuron activity.
- •
A functioning cell/transistor hybrid structure is demonstrated.