Novel analogs of alloferon: Synthesis, conformational studies, pro-apoptotic and antiviral activity
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- 作者：Mariola Kuczera ; mariola.kuczer@chem.uni.wroc.pl" class="auth_mail" title="E-mail the corresponding author ; Elżbieta Czarniewskab ; Anna Majewskac ; Maria Ró ; żanowskaa ; Grzegorz Rosińskib ; Marek Lisowskia
- 关键词：CD ; circular dichroism ; CPE ; cytopathic effect ; DMF ; dimethylformamide ; FBS ; fetal bovine serum ; Fmoc ; 9-fluorenylmethoxycarbonyl ; HBTU ; O-benzotriazole-N ; N ; N&prime ; N&prime ; -tetramethyl-uronium-hexafluorophosphate ; HOBt ; N-hydroxybenzotriazole ; HPLC ; high performance liquid chromatography ; MTT ; 3-[4 ; 5-dimethylthiazol-2-yl]-2 ; 5-diphenyl tetrazolium bromide ; NMM ; N-methylmorpholine ; TCID ; tissue culture infected dose ; TFA ; trifluoroacetic acid ; TIS ; triisopropylsilane ; UV ; ultraviolet
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：12-20
- 全文大小：1770 K
文摘
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Several novel analogs of alloferon modified at position 9 or 12 were synthesized.
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Some analogs strongly induce T. molitor hemocytes to undergo apoptosis.
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Most of the investigated peptides inhibit the replication of HHV-1MC in Vero cells.
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The structure-activity relationship of alloferon is discussed.