The G protein estrogen receptor (GPER) is regulated by endothelin-1 mediated signaling in cancer cells
详细信息 查看全文
- 作者：Viviana Bartella ; Ernestina Marianna De Francesco ; Maria Grazia Perri ; Rosita Curcio ; Vincenza Dolce ; Marcello Maggiolini ; marcellomaggiolini@yahoo.it" class="auth_mail" title="E-mail the corresponding author ; marcello.maggiolini@unical.it" class="auth_mail" title="E-mail the corresponding author ; Adele Vivacqua
- 关键词：ET-1 ; endothelin-1 ; ETAR ; endothelin receptor A ; ETBR ; endothelin receptor B ; PI3K ; phosphatidylinositol 3-kinase ; ERK ; extracellular signal-regulated kinase ; CTGF ; connective tissue growth factor ; Egr-1 ; early related gene ; HIF-1 ; hypoxia inducible factor-1 ; VEGF ; vascular endothelial growth factor
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：28
- 期：2
- 页码：61-71
- 全文大小：1656 K
文摘
- •
ET-1 up-regulates GPER expression.
- •
GPER contributes to cancer cell migration induced by ET-1.
- •
GPER is involved in tube-like formation induced by ET-1 in HUVECs.