Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
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- 作者：Mary Gazeaa ; 1 ; 2 ; Evangelia Tasourib ; c ; 1 ; Marianna Tolvea ; Viktoria Boscha ; Anna Kabanovaa ; Christian Gojakd ; e ; 3 ; Bahtiyar Kurtulmusf ; Orna Novikovg ; Joachim Spatzd ; e ; Gislene Pereiraf ; Wolfgang Hü ; bnerh ; Claude Brodskig ; Kerry L. Tuckerb ; c ; i ; ktucker2@une.edu" class="auth_mail" title="E-mail the corresponding author ; Sandra Blaessa ; sblaess@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Primary cilia ; Ift88 ; Intraflagellar transport ; Midbrain ; Dopaminergic neurons ; Shh
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：409
- 期：1
- 页码：55-71
- 全文大小：12358 K
文摘
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Ift88 is essential for normal primary cilia function in the ventral midbrain.
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Midbrain-inactivation of Ift88 results in loss of Shh signaling and mDA precursors.
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An Ift88 hypomorphic mutant (cbbs) maintains clusters of Shh-responding cells.
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The dopaminergic neuron precursor domain is not established in cbbs mutants.
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Functional primary cilia are required for induction of dopaminergic precursors.