Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration

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• 作者：Elisa Pedone¹ ; ² ; Vlad-Aris Olteanu³ ; Lucia Marucci¹ ; ³ ; ^{lucia.marucci@bristol.ac.uk} ; Maria Isabel Muñ ; oz-Martin¹ ; Sameh A. Youssef⁴ ; ⁵ ; Alain de Bruin⁴ ; ⁶ ; Maria Pia Cosma¹ ; ² ; ⁷ ; ⁸ ; ^{pia.cosma@crg.es}
• 关键词：cell fusion ; mathematical modeling ; liver regeneration ; partial hepatectomy ; hematopoietic stem cells ; cell migration ; cell recruitment ; proliferation ; systems biology
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：107-121
• 全文大小：4100 K
• 卷排序：18

文摘

Bone marrow cell migration after liver hepatectomy is key for liver regeneration Migrated bone marrow cells fuse with hepatocytes Hybrids are essential for liver regeneration Mathematical modeling unveils the hybrid function for liver regeneration