A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes
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- 作者：Claudio Giachino1 ; claudio.giachino@unibas.ch" class="auth_mail" title="E-mail the corresponding author ; Jean-Louis Boulay2 ; Robert Ivanek1 ; Alvaro Alvarado3 ; Cristobal Tostado2 ; Sebastian Lugert1 ; Jan Tchorz4 ; Mustafa Coban1 ; Luigi Mariani2 ; Bernhard Bettler4 ; Justin Lathia3 ; Stephan Frank5 ; Stefan Pfister6 ; Marcel Kool6 ; Verdon Taylor1 ; verdon.taylor@unibas.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：brain tumor ; glioma ; primitive neuroectodermal tumor ; Notch signaling ; Hes5
- 刊名：Cancer Cell
- 出版年：2015
- 出版时间：14 December 2015
- 年：2015
- 卷：28
- 期：6
- 页码：730-742
- 全文大小：5200 K
文摘
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Notch signaling and p53 cooperate to reduce initiation of forebrain tumor subtypes
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Anti-tumorigenic effects of Notch are linked to regulation of quiescence
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Inhibiting Notch promotes a primitive neuroectodermal-like tumor fate
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Low Notch activity correlates with poor prognosis for patients with glioma subtypes