Relation of Combined Non-High-Density Lipoprotein Cholesterol and Apolipoprotein B With Atherosclerosis in聽Adults With Type 1 Diabetes Mellitus

详细信息    查看全文

• 作者：Petter Bjornstad ; MD^a ; ^b ; ^{petter.m.bjornstad@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author} ; Robert H. Eckel ; MD^c ; Laura Pyle ; PhD^a ; Marian Rewers ; MD ; PhD^a ; ^b ; David M. Maahs ; MD ; PhD^a ; ^b ; Janet K. Snell-Bergeon ; PhD ; MPH^a ; ^b
• 刊名：The American Journal of Cardiology
• 出版年：2015
• 出版时间：1 October 2015
• 年：2015
• 卷：116
• 期：7
• 页码：1057-1062
• 全文大小：625 K

文摘

Apolipoprotein B (apoB) and non–high-density lipoprotein cholesterol (non-HDL-C) are cardiovascular disease risk markers, although data in adults with type 1 diabetes mellitus (DM) are limited. We hypothesized that elevated apoB and non-HDL-C would be associated with greater odds of coronary artery calcification progression (CACp), a measure of coronary atherosclerosis, than either category alone in adults with type 1 DM. We grouped subjects with type 1 DM (n = 652) into 4 groups: elevated apoB (≥90 mg/dl) and elevated non-HDL-C (≥130 mg/dl), elevated non-HDL-C alone, elevated apoB alone, and normal apoB and non-HDL-C. We used logistic regression to examine the associations between the groups and CACp for a period of 6 years. We performed sensitivity analyses with elevated apoB and non-HDL-C redefined as at or more than the cohort means (91.4 and 119.0 mg/dl, respectively). Subjects with elevated apoB and non-HDL-C had greater odds of CACp compared with those with normal apoB and non-HDL-C (odds ratio 1.90, 95% confidence interval 1.15 to 3.15) and compared with subjects with elevated apoB alone (odds ratio 2.86, 95% confidence interval 1.43 to 5.74) adjusting for age, gender, duration, hemoglobin A1c, and statins. Similar results were obtained with elevated apoB and non-HDL-C defined as at or more than the cohort means. In conclusion, elevated apoB and non-HDL-C carry a greater risk of atherosclerosis than elevated apoB in the absence of elevated non-HDL-C in adults with type 1 DM. These data suggest that apoB and non-HDL-C should be viewed as complementary rather than competitive indexes of cardiovascular disease risk in type 1 DM.