MICA-HLA-B haplotype diversity and linkage disequilibrium in a population of Jewish descent from Majorca (the Balearic Islands)

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• 作者：Ana Cambra ; Iv&#xe1 ; n Muñ ; oz-Sa&#xe1 ; Catalina Cresp&#xed ; Antò ; nia Serra ; Aitziber Etxagibel ; Nú ; ria Matamoros ; Joan Mil&#xe0 ; Maria Rosa Juli&#xe0
• 关键词：Chueta ; HLA-B ; Linkage disequilibrium ; MICA polymorphism ; Non-Ashkenazi Jews
• 刊名：Human Immunology
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：70
• 期：7
• 页码：513-517
• 全文大小：405 K

文摘

The major histocompatibility complex class I chain-related A (MICA) gene is located 46 kb centromeric of human leukocyte antigen (HLA)-B and is highly polymorphic, similar to HLA genes. This allelic variation may influence the affinity of MICA molecules to their receptor on natural killer, γδ T and CD8⁺ T cells, NKG2D, and the immune response to organ transplantation and disease susceptibility. In the present study, we typed MICA and HLA-B polymorphisms in 95 individuals from a population of Jewish descent (Chuetas) and 195 individuals of Caucasian origin from Majorca (the Balearic Islands). MICA*008, -*004, and -*002 were the most common alleles and accounted for 53 and 60 % in Chuetas and Majorcans, respectively. Other common alleles (frequency >5 % ) were MICA*016, -*009, -*012, -*007, and -*017 in Chuetas and -*009, -*001, and -*018 in Majorcans. We also studied two-locus haplotype diversity and linkage disequilibrium (LD). Both populations presented haplotypes with significant LD that were shared by other Caucasians populations, but we reported particular haplotypes in the Chueta group: MICA*002–HLA-B*38, MICA*016–HLA-B*35, MICA*012–HLA-B*55, and MICA*017–HLA-B*57. These haplotypes were not reported in other studies at high frequencies. In conclusion, the Chueta population presents a particular genetic pool but has affinities with the host population.