CKβ8, a novel CC chemokine that predominantly acts on monocytes

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• 作者：Forssmann ; Ulf ; Delgado ; Maria Belen ; Uguccioni ; Mariagrazia ; Loetscher ; Pius ; Garotta ; Gianni ; et. al.
• 关键词：Expression ; Chemotaxis ; Secretion ; Receptor ; Desensitization ; MIP ; macrophage inflammatory protein ; MCP ; monocyte chemoattractant protein ; RANTES ; regulated on activation ; normal T expressed and secreted ; [Ca²⁺]_i ; cytosolic free calc
• 刊名：FEBS Letters
• 出版年：1997
• 出版时间：May 19, 1997
• 年：1997
• 卷：408
• 期：2
• 页码：211-216
• 全文大小：695 K

文摘

We have studied the biological properties of a new human CC chemokine, CKβ8, consisting of 99 amino acids including six cysteines. CKβ8 mRNA transcripts were induced in monocytes by IL-1β and, to a lesser extent, by IFNγ, and were detected in RNA extracted from normal human liver and gastrointestinal tract. CKβ8 is chemotactic for monocytes, but is inactive on IL-2 conditioned T lymphocytes, eosinophils and neutrophils. Desensitization experiments indicate that CKβ8 and MIP-1β completely share receptors on monocytes and that the CKβ8 receptor, which appears to differ from the known ones, is also recognized by MCP-1, MCP-2, MCP-3, MCP-4, MIP-1α and RANTES.