Antiparasitic activity of menadione (vitamin K₃) against Schistosoma mansoni in BABL/c mice

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• 作者：Govind J. Kapadia^a ; ¹ ; Ingrid A.O. Soares^b ; G. Subba Rao^c ; Fernanda R. Badoco^b ; Ricardo A. Furtado^b ; Mariana B. Correa^b ; Denise C. Tavares^b ; Wilson R. Cunha^b ; Lizandra G. Magalhã ; es^b ; ^{lizandra.magalhaes@unifran.edu.br}
• 关键词：Menadione ; Naphthoquinone ; Schistosoma mansoni ; Vitamin K3
• 刊名：Acta Tropica
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：163-173
• 全文大小：2824 K
• 卷排序：167

文摘

LC50 of menadione (MEN) against S. mansoni adult worms in vitro was 10.49 ± 1.02 μM at 24 h. MEN induced alterations on tegument and organelles of S. mansoni adult worms in vitro. MEN increased superoxide anion levels in S. mansoni adult worms in vitro. MEN reduced the number of worms and egg formation in S. mansoni-infected mice in vivo. Above effects of MEN compared reasonably well to currently used drug, praziquantel.