A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts
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- 作者：Tyler N. Graf<sup>asup> ; Nadja B. Cech<sup>asup> ; Stephen J. Polyak<sup>bsup><sup> ; sup><sup>csup><sup> ; sup><sup>dsup> ; Nicholas H. Oberlies<sup>asup><sup> ; sup><sup>nicholas_oberlies@uncg.edu" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Milk thistle ; Silybum marianum ; Flavonolignans ; Silymarin ; Validation
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：26-33
- 全文大小：956 K
文摘
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A rapid, validated method for the quantitation of seven flavonolignans and the flavonoid, taxifolin, all isolated from milk thistle (Silybum marianum), was developed.
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The method utilized UPLC coupled to both a mass spectrometer and a photodiode detector.
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The suite of compounds was evaluated in a variety of milk thistle products, quantifying variability.
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The extent of breakdown of these compounds was evaluated upon storage in DMSO.