Protease-activated receptor-2 (PAR₂) in cardiovascular system

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• 作者：Mariarosaria Bucci ; Fiorentina Roviezzo and Giuseppe Cirino
• 关键词：PAR₂ ; Vascular reactivity ; Endothelium ; G-protein
• 刊名：Vascular Pharmacology
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：43
• 期：4
• 页码：247-253
• 全文大小：155 K

文摘

Vascular system is constituted by a complex and articulate network, e.g. arteries, arterioles, venules and veins, that requires a high degree of coordination between different elemental cell types. Proteinase-activated receptors (PARs) constitute a recent described family of 7-transmembrane G protein-coupled receptors that are activated by proteolysis. In recent years several evidence have been accumulated for an involvement of this receptor in the response to endothelial injury in vitro and in vivo experimental settings suggesting a role for PAR₂ in the pathophysiology of cardiovascular system.

This review will deal with the role of PAR₂ receptor in the cardiovascular system analyzing both in vivo and in vitro published data. In particular this review will deal with the role of this receptor in vascular reactivity, ischemia/reperfusion injury, coronary atherosclerotic lesions and angiogenesis.