ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome

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• 作者：Sanjeev Mariathasan
• 关键词：ASC ; Ipaf ; Cryopyrin ; Nalp3 ; Inflammasome
• 刊名：Microbes and Infection
• 出版年：2007
• 出版时间：April 2007
• 年：2007
• 卷：9
• 期：5
• 页码：664-671
• 全文大小：271 K

文摘

The adapter molecules ASC, Ipaf and Cryopyrin/Nalp3 have each been proposed to regulate caspase-1 within a multi-protein complex called the “inflammasome”. Activation of caspase-1 leads to the cleavage and activation of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-18. The analysis of mice deficient in ASC, Ipaf and Cryopyrin/Nalp3 has revealed that the inflammasome is a dynamic entity that is assembled from different adapters in a stimulus-dependent manner.