Differences in promoter DNA methylation and mRNA expression of individual alleles of the HLA class II DQA1 gene
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- 作者：Marta Zajacova marta.zajac17@gmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Anna Kotrbova-Kozak anna.kotrbova@lf3.cuni.cz" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Pavel Cepek pa.cepek9@gmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Marie Cerna ; marie.cerna@lf3.cuni.cz" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：QAP ; allele ; DQA1 ; promoter allele
- 刊名：Immunology Letters
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：167
- 期：2
- 页码：147-154
- 全文大小：675 K
文摘
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DNA methylation pattern of DQA1 gene promoter alleles was described.
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DQA1*02:01 and *04:01 alleles methylation is increased.
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DQA1*05:01 allele shows lowest methylation level.
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DQA1*03 is the most and DQA1*05:05 the least expressed allele.
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No correlation between promoter DNA methylation and gene expression was identified.