Emerging toxicity of 5,6-methylenedioxy-2-aminoindane (MDAI): Pharmacokinetics, behaviour, thermoregulation and LD50 in rats
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- 作者：Tomá ; &scaron ; Pá ; lení ; čeka ; c ; tomas.palenicek@nudz.cz" class="auth_mail" title="E-mail the corresponding author ; Eva Lhotková ; a ; Monika Ží ; dková ; b ; Marie Balí ; ková ; b ; Martin Kuchařa ; d ; Michal Himld ; Petra Mik&scaron ; á ; tková ; a ; d ; Martin Čegane ; Karel Vale&scaron ; a ; Filip Tyl&scaron ; a ; c ; Rachel R. Horsleya
- 关键词：2-AI ; 2-aminoindane ; 5-IAI ; 5-iodo-2-aminoindane ; ASR ; acoustic startle response ; DAT ; dopamine transporter ; EMCDDA ; European Monitoring Centre for Drugs and Drug Addiction ; HPLC ; high performance liquid chromatography ; HCl ; hydrochloride ; HESI ; heated electrospray ionisation ; ITI ; inter-trial interval ; ISI ; inter-stimulus interval ; iv. ; intravenous ; LC/MS ; liquid chromatography with mass spectrometry ; LC/HRMS ; liquid chromatography with high resolution mass spectrometry ; LD50 ; median lethal dos
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：49-59
- 全文大小：677 K
文摘
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MDAI induces locomotor stimulant effects and behavioural serotonin syndrome
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MDAI disrupts sensorimotor processing
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MDAI accumulates in the brain and liver compared to serum
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MDAI increases body temperature and induces profuse perspiration under aggregated conditions
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LD50 after sc. administration in aggregated condition is 28.33 mg/kg (symptoms of multiorgan failure, DIC and brain oedema).