Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration
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- 作者：Zhiming Wanga ; b ; wangzm@sj-hospital.org" class="auth_mail" title="E-mail the corresponding author ; Shizhang Lingb ; Eleni Rettigb ; Ryan Sobelb ; Marietta Tanb ; Elana J. Fertigc ; Michael Considinec ; Adel K. El-Naggard ; Mariana Braitb ; Carole Fakhryb ; e ; Patrick K. Hab ; e ; pha1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Head and neck cancer ; Mucoepidermoid carcinoma ; DNA methylation ; Array ; Bisulfite sequencing ; Methylation-specific PCR ; CLIC3 ; Immunohistochemistry ; H-score
- 刊名：Oral Oncology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：51
- 期：12
- 页码：1120-1125
- 全文大小：1153 K
文摘
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The HumanMethylation27 BeadChip array was used in a cohort of mucoepidermoid carcinoma.
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The increased protein expression of CLIC3 via IHC was noted in MEC versus normal salivary gland tissues.
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CLIC3 was found to have significant hypomethylation in these MEC tumors.