The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus
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- 作者：Madoka Narushima1 ; Motokazu Uchigashima2 ; Yuki Yagasaki1 ; Takeshi Harada3 ; Yasuyuki Nagumo1 ; Naofumi Uesaka4 ; Kouichi Hashimoto5 ; Atsu Aiba3 ; Masahiko Watanabe2 ; Mariko Miyata1 ; mmiyata@twmu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masanobu Kano4 ; mkano-tky@m.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：7 September 2016
- 年：2016
- 卷：91
- 期：5
- 页码：1097-1109
- 全文大小：4374 K
文摘
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Dark rearing (DR) causes remodeling of established retinogeniculate synapse (RGS)
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Deletion or blockade of mGluR1 in mice causes similar remodeling of RGS
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mGluR1 deletion occludes, and mGluR1 activation rescues, the DR-induced RGS remodeling
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mGluR1 is essential for visual-experience-dependent maintenance of mature RGS