Exploration of physical and chemical cues on retinal cell fate
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- 作者：Marina Castro Zalisa ; marina.castro_zalis@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Sebastian Johanssona ; atn09sjo@student.lu.se" class="auth_mail" title="E-mail the corresponding author ; Fredrik Johanssonb ; per_fredrik.johansson@biol.lu.se" class="auth_mail" title="E-mail the corresponding author ; Ulrica Englund Johanssona ; ulrica.englund_johansson@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：AB ; AlamarBlue ; CNS ; Central Nervous System ; DIV ; Days in vitro ; ECM ; Extracellular matrix ; FFT ; Fast Fourier Transform ; PCL ; Poly-ε-caprolactone ; PLL ; Poly-l-lysine ; PLLA ; Poly-l-lactic acid ; PN4 ; Post-natal day 4 ; RPNCs ; Retinal post-natal cells ; RGCs ; Retinal ganglion cells ; RPC ; Retinal progenitor cells ; RT ; Room temperature ; SD ; Standard deviation of a sample ; SEM ; Scanning electron microscope ; SEM ; Standard error of mean
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：122-132
- 全文大小：1742 K
文摘
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Nanotopography per se significantly affects retinal cell morphology.
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Laminin in combination with neurotrophins promotes retinal cell– morphology, fate, and neurite extension.
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Laminin induces a remarkable 90° switch of retinal neurite orientation.
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Chemical cues are necessary to tune the physical cue.