Proviral load and the balance of serum cytocines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

详细信息    查看全文

• 作者：Ana Lú ; cia Borges Starling^a ; Olindo Assis Martins-Filho^b ; José ; Roberto Lambertucci^a ; Ludimila Labanca^a ; Silvio Roberto de Souza Pereira^a ; André ; a Teixeira-Carvalho^b ; Marina Lobato Martins^c ; Jo&atilde ; o Gabriel Ribas^d ; Anna Bá ; rbara F. Carneiro-Proietti^c ; ^e ; Denise Utsch Gonç ; alves^a ; ^{deniseg@medicina.ufmg.br} ; ^{oamfilho@cpqrr.fiocruz.br}
• 关键词：HTLV-1 ; HAM/TSP ; Proviral load ; Cytokine
• 刊名：Acta Tropica
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：125
• 期：1
• 页码：75-81
• 全文大小：761 K

文摘

This study compared the proviral load and the plasma cytokine profiles (interleukin-IL-2, IL-4, IL-6, IL-10, TNF-¦Á, IFN-¦Ã) in 87 HTLV-1-infected individuals, including 28 with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 32 with possible pHAM/TSP and 27 asymptomatic carriers (AC). The control group was composed by 21 HTLV-1-seronegative individuals. Our finding demonstrated that HAM/TSP group presented higher proviral load as compared to all other HTLV-1 groups (p < 0.0001). The HAM/TSP group showed higher serum concentration of IL-6 (p = 0.0009) as compared to all other groups. Moreover, higher serum concentration of IFN-¦Ã (p = 0.0118) and IL-4 (p = 0.0166) were observed in HAM/TSP group as compared to the healthy controls. Additionally, the HAM/TSP group also showed higher serum concentration of TNF-¦Á (p = 0.0239) and IFN-¦Ã (p = 0.0118) as compared to AC. No differences in the serum concentration of IL-2 and IL-10 were observed among the groups. The analysis of cytokine balance demonstrated that HAM/TSP presented higher pro-inflammatory profile with enhanced IFN-¦Ã/IL-10 and IFN-¦Ã/IL-4 ratio as compared to AC and pHAM/TSP. Further analysis pointed out to a positive correlation between the IFN-¦Ã response and the proviral load in AC. Conversely, a negative association between TNF-¦Á and IL-2 with the proviral load was the hallmark of HAM/TSP group. These findings suggested that the proviral load and the pro-inflammatory cytokine profile may be independent events in the peripheral blood of HAM/TSP individuals. The knowledge about the existence of individual virological/immunological behavior upon HTLV-1 infection, may guide to the establishment of more effective therapeutic interventions.