Solid-state investigation of fluocinolone acetonide

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• 作者：Bartolomei ; Monica ; Ramusino ; Marina Cotta ; Ghetti ; Paolo
• 关键词：Fluocinolone acetonide ; Physico-chemical characterization ; Polymorphism ; Infrared spectroscopy ; Thermal analysis ; X-ray diffractometry
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：1997
• 出版时间：August, 1997
• 年：1997
• 卷：15
• 期：1
• 页码：1813-1820
• 全文大小：474 K

文摘

Three crystalline modifications of fluocinolone acetonide, A, B and C, were characterized by means of FTIR, DSC, TG-FTIR, MICRO-FTIR and X-ray diffractometry. They were easily differentiated by their IR absorption bands in the 3600-3400 cm⁻¹ range. The thermal behaviour was also elucidated using combined techniques; thermomicroscopy and thermogravimetry coupled with Fourier transform infrared spectroscopy were found to be very useful tools for a better understanding of thermal events. On heating, form A and C were fully converted into form B. Polymorph A was found to be enantiotropically related to B, while form C was monotropically related to B. The existence of three polymorphs was confirmed by means of their different X-ray diffraction patterns. Detailed methods of preparation of the three modifications are also described.