HCV NS3 quasispecies in liver and plasma and dynamics of telaprevir-resistant variants in breakthrough patients assessed by UDPS: A case study
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- 作者：Barbara Bartolini1 ; Marina Selleri1 ; Anna Rosa Garbuglia ; Emanuela Giombini ; Chiara Taibi ; Raffaella Lionetti ; Gianpiero D'Offizi ; Maria R. Capobianchi ; maria.capobianchi@inmi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCV ; NS3 ; Diversity ; Viral quasispecies ; Resistance associated mutations ; Ultra-deep pyrosequencing
- 刊名：Journal of Clinical Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：72
- 期：Complete
- 页码：60-65
- 全文大小：2477 K
文摘
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HCV NS3 quasispecies in two TVR-failed patients has been assessed by UDPS.
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Baseline diversity in plasma was higher than in liver.
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The baseline frequency of RAMs was very low in both compartments.
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Phylogenetic trees did not evidence compartmentalization between plasma and liver.
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Baseline RAM-harboring variants seem different from those fixed at breakthrough.