Interleukin-6 in inflammatory and malignant diseases of the pancreas

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• 作者：Marina Lesina ; Sonja Maria Wö ; rmann ; Patrick Neuhö ; fer ; Liang Song ; Hana Algü ; l ; ^{hana.alguel@lrz.tum.de" class="auth_mail}
• 关键词：PDAC ; pancreatic ductal adenocarcinoma ; PanINs ; pancreatic intraepithelial neoplasias ; IPMNs ; intraductal papillary mucinous neoplasms ; Kras ; kirsten rat sarcoma viral oncogene homolog ; p16/CDKN2A ; cyclin-dependent kinase inhibitor 2A ; TP53 ; tumor protein 53 ; DPC4/SMAD4 ; mothers against decapentaplegic homolog 4 ; TGF_RI ; TGF_RII ; transforming growth factor-尾 receptors type I and II ; respectively ; GEMM ; genetically engineered mouse models ; TAM ; tumor associated macrophage ; Th1 ; T helper type 1 c
• 刊名：Seminars in Immunology
• 出版年：February, 2014
• 年：2014
• 卷：26
• 期：1
• 页码：80-87
• 全文大小：1786 K

文摘

Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.