Molecular organization of the basement membrane zone

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• 作者：Sana Hashmi BS^a ; M. Peter Marinkovich MD^b ; ^c ; ^{mpm@stanford.edu"" rel=""nofollow}
• 刊名：Clinics in Dermatology
• 出版年：2011
• 出版时间：July-August 2011
• 年：2011
• 卷：29
• 期：4
• 页码：398-411
• 全文大小：1513 K

文摘

The dermal-epidermal basement membrane is a complex assembly of proteins that provide adhesion and regulate many important processes such as development, wound healing, and cancer progression. This contribution focuses on the structure and function of individual components of the basement membrane, how they assemble together, and how they participate in human tissues and diseases, with an emphasis on skin involvement. Understanding the composition and structure of the basement membrane provides insight into the pathophysiology of inherited blistering disorders, such as epidermolysis bullosa, and acquired bullous diseases, such as the pemphigoid group of autoimmune diseases and epidermolysis bullosa acquisita.