An efficient biocatalytic system for floxuridine biosynthesis based on Lactobacillus animalis ATCC 35046 immobilized in Sr-alginate
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- 作者：Valeria A. Cappa ; Cintia W. Rivero ; Claudia N. Britos ; Luis M. Martinez ; Mario E. Lozano ; Jorge A. Trelles ; jtrelles@unq.edu.ar" class="auth_mail ; jatrelles@gmail.com" class="auth_mail
- 关键词：Lactic acid bacteria ; Halogenated 2&prime ; -deoxyribosides ; Microorganism stabilization ; Co-solvents ; Anti-tumoral compounds
- 刊名：Process Biochemistry
- 出版年：July 2014
- 年：2014
- 卷：49
- 期：7
- 页码：1169-1175
- 全文大小：928 K
文摘
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L. animalis ATCC 35046 was efficiently immobilized in Sr-alginate beads.
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Sr-alginate biocatalyst was able to reach 96% of floxuridine.
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Using hexane as co-solvent, the obtained biocatalyst was able to produce 80% of 5BrUradRib.
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The reusability of biocatalyst was enhanced 2-fold respect previous reports.