High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease
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- 作者：Yaroslau Compta ; Mario Ezquerra ; Esteban Muñ ; oz ; Eduardo Tolosa ; Francesc Valldeoriola ; Jose Rios ; Ana Cá ; mara ; Manel Ferná ; ndez ; Maria Teresa Buongiorno ; Maria Jose Marti
- 关键词：Cerebrospinal fluid ; Tau ; Amyloid-β ; Parkinson disease ; Dementia ; Alzheimer disease
- 刊名：Neuroscience Letters
- 出版年：2011
- 出版时间：7 January 2011
- 年：2011
- 卷：487
- 期：2
- 页码：169-173
- 全文大小：183 K
文摘
Cerebrospinal fluid (CSF) tau and phospho-tau levels have been associated with certain tau gene variants and low CSF amyloid-β (Aβ) levels in Alzheimer disease (AD), constituting potential biomarkers of molecular mechanisms underlying neurodegeneration. We aimed to assess whether such CSF-genetic endophenotypes are also present in Parkinson disease (PD). CSF tau, phospho-tau and Aβ levels were obtained from 38 PD patients (19 with dementia) using specific ELISA techniques. All cases were genotyped for a series of tau gene polymorphisms (rs1880753, rs1880756, rs1800547, rs1467967, rs242557, rs2471738 and rs7521). The A-allele rs242557 polymorphism was the only tau gene variant significantly associated with higher CSF tau and phospho-tau levels, under both dominant and dose–response model. This association depended on the presence of dementia, and was only observed in individuals with low (<500 pg/mL) CSF Aβ levels. Such genetic-CSF endophenotypes are probably a reflection of the presence of AD-like molecular changes in part of PD patients in the setting of dementia.