Bridging-therapy with intravenous recombinant tissue plasminogen activator improves functional outcome in patients with endovascular treatment in acute stroke
Bridging with IVT in patients undergoing mechanical thrombectomy was associated with improved neurological function. In patients with bridging therapy with IVT there was a trend towards a higher rate of successful recanalization. Early allocation and systemic effects of IVT on stroke recurrence and penumbra-perfusion might have an influence. Larger trials are needed to confirm our findings and to investigate subgroups benefitting most from bridging with IVT.