Recombinant S3Pvac-phage anticysticercosis vaccine: Simultaneous protection against cysticercosis and hydatid disease in rural pigs

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• 作者：Julio Morales^a ; Aline S. de Aluja^b ; Jose Juan Mart&#xed ; nez^b ; Marisela Hern&#xe1 ; ndez^a ; Gabriela Rosas^c ; Nelly Villalobos^b ; Beatriz Hern&#xe1 ; ndez^d ; Abel Blancas^a ; Karen Manoutcharian^a ; Goar Gevorkian^a ; Jacquelynne Cervantes^a ; Alicia D&#xed ; az^e ; AgnesFleury^f ; Gladis Fragoso^a ; Carlos Larralde^a ; Edda Sciutto^a ; ^{edda@servidor.unam.mx}
• 关键词：Filamentous phages ; Vaccination ; Cysticercosis ; Hydatidosis ; Taenia solium ; Echinococcus granulosus
• 刊名：Veterinary Parasitology
• 出版年：2011
• 出版时间：28 February 2011
• 年：2011
• 卷：176
• 期：1
• 页码：53-58
• 全文大小：572 K

文摘

This paper provides macroscopic and histological evidence on the statistically significant protective effects of S3Pvac-phage vaccination against porcine cysticercosis and hydatidosis. The study included 391 rustically bred pigs (187 vaccinated and 204 controls). Vaccination significantly reduced the prevalence of cysticercosis by 61.7 % . Vaccination also significantly reduced by 56.1 % the prevalence of hydatidosis caused by Echinococcus granulosus in pigs. The presence of the vaccine epitopes in both cestodes is probably involved in the cross-protection observed. Increased inflammation was found in 5 % of cysticerci recovered from controls, versus 24 % from vaccinated pigs (P < 0.01). Hydatid cysts were non-inflammatory in either group. Vaccination was effective to prevent one single disease, but it failed to prevent the simultaneous infections with both parasites in a same pig. The widening of the S3Pvac-phage vaccine protective repertoire to include hydatidosis is a convenient feature that should reduce the prevalence of two frequent zoonoses that affect rustic porcine breading with a single action. Thus, the costs of two different vaccination programs would be reduced to a single one with significant reduction in both zoonoses.