Synthesis, characterization and antiproliferative activity of ¦Â-aryl-¦Ä-iodo-¦Ã-lactones
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- 作者：Alicja Wzorek ; Barbara Gawdzik ; Witold G?adkowski ; Mariusz Urbaniak ; Anita Bara¨½ska ; Maura Mali¨½ska ; Krzysztof Wo?niak ; Katarzyna Kempi¨½ska ; Joanna Wietrzyk
- 关键词：Lactones ; Iodolactonization ; Crystal structure ; Intermolecular interactions ; Antiproliferative activity
- 刊名：Journal of Molecular Structure
- 出版年：2013
- 出版时间：5 September, 2013
- 年：2013
- 卷：1047
- 期：Complete
- 页码：160-168
- 全文大小：1281 K
文摘
A convenient pathway for the synthesis of new of ¦Â-aryl-¦Ä-iodo-¦Ã-lactones is described. The synthetic route led to both cis and trans isomers which were separated by column chromatography or crystallization. The structures of synthesized compounds were confirmed by spectroscopic methods: IR, NMR and HR-MS. For lactones with naphthyl ring (6e and 7e) the crystal structures were also obtained. The lactones were screened for biological evaluation against cancer line HL-60 (human promyelocytic leukemia). The tests showed that the presence of substituent at the benzene ring does not significantly affect the antiproliferative activity of the compound.