Beneficial effect of the CXCL12-3鈥睞 variant for patients undergoing hematopoietic stem cell transplantation from unrelated donors
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- 作者：Katarzyna Bogunia-Kubika ; bogunia@iitd.pan.wroc.pl" class="auth_mail" title="E-mail the corresponding author ; Sylwia Miziab ; Ma艂gorzata Polakb ; Anna Gronkowskac ; Jacek Nowakd ; S艂awomira Kyrcz-Krzemie艅e ; Miros艂aw Markiewicze ; Monika Dzier偶ak-Miet艂ae ; Anna Kocl臋gae ; Mariola S臋dzimirskab ; Krzysztof Suchnickib ; Dorota Dudab ; Janusz Langeb ; Monika Mordak-Domaga艂ab ; Katarzyna Ko艣ci艅skab ; Wies艂aw Wiktor J臋drzejczakc ; Beata Kaczmarekc ; Andrzej Hellmannf ; Agnieszka Kucharskaf ; Jerzy Kowalczykg ; Katarzyna Drabkog ; Krzysztof Warzochad ; Kazimierz Ha艂aburdad ; Agnieszka Tomaszewskad ; Renata Mika-Witkowskad ; Agnieszka Witkowskad ; Jolanta Go藕dzikh ; Anna Mordelh ; Barbara Wysocza艅skaa ; Emilia Jaskulaa ; b ; Andrzej Langea ; b ; on behalf of the POLISH DONOR&ndash ; RECIPIENT STUDY GROUP
- 关键词：CXCL12 polymorphism ; Hematopoietic stem cell transplantation from alternative donors ; Toxicity ; Graft-versus-host disease ; Viral reactivation
- 刊名：Cytokine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：76
- 期：2
- 页码：182-186
- 全文大小：530 K
文摘
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CXCL12 gene polymorphism (rs1801157) affects the outcome of unrelated HSCT.
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CXCL12-3′-A allele in donors associates with lower risk of toxic complications.
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Acute GvHD incidence is lower in patients having CXCL12-3′-A allele and AA homozygous genotype.
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CXCL12-3′-A-positive patients are less prone to early HHV-6 reactivation.
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CXCL12-3′-A variant plays a beneficial role in unrelated HSCT.