Prostaglandin E2 exerts the proapoptotic and antiproliferative effects on bovine NK cells
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- 作者：Tomasz Maślankaa ; tomasz.maslanka@uwm.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Małgorzata Chrostowskab ; Iwona Otrocka-Domagałac ; Anna Snarskad ; Mateusz Mikiewiczd ; Monika Zuśka-Prota ; Agnieszka Jasieckaa ; Hubert Zió ; łkowskia ; Włodzimierz Markiewicza ; Jerzy J. Jaroszewskia
- 关键词：NK cells ; PGE2 ; EP receptor ; Apoptosis ; Proliferation ; Cattle
- 刊名：Research in Veterinary Science
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：80-87
- 全文大小：1208 K
文摘
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PGE2 at certain concentrations exerts a proapoptotic effect on bovine NK cells7.
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Blockade of EP1–4 receptors does not prevent the PGE2-induced apoptosis of NK cells.
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PGE2 at certain concentrations impairs the proliferation of NK cells in cattle.
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Anti-proliferative action of PGE2 on bovine NK cells is mediated via the EP4 receptor