Cholesterol metabolism in cardiac sarcoidosis
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- 作者：Piia Simonena ; piia.simonen@hus.fi" class="auth_mail" title="E-mail the corresponding author ; Jukka Lehtonena ; jukka.lehtonen@hus.fi" class="auth_mail" title="E-mail the corresponding author ; Helena Gyllingb ; helena.gylling@hus.fi" class="auth_mail" title="E-mail the corresponding author ; Markku Kuparia ; markku.kupari@hus.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; Campesterol ; Cholesterol absorption ; Cholesterol synthesis ; Inflammation ; Lathosterol ; Myocardial disease
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：248
- 期：Complete
- 页码：210-215
- 全文大小：241 K
文摘
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Atherosclerotic risk factors, ie perturbed serum lipids and whole-body cholesterol metabolism, remain unknown in cardiac sarcoidosis (CS).
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Cholesterol metabolism was evaluated in 39 patients with histologically verified CS and in an age- adjusted random population sample (n = 124).
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Cholesterol absorption was upregulated and cholesterol synthesis downregulated in CS. Serum lipids were similar between groups.
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High cholesterol absorption efficiency, suggested to be atherogenic, characterised the metabolic profile of cholesterol in CS.