Demographics and Epidemiology of Sudden Deaths in Young Competitive Athletes: From the United States National Registry

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• 作者：Barry J. Maron ; MD ; ^{hcm.maron@mhif.org" class="auth_mail" title="E-mail the corresponding author} ; Tammy S. Haas ; RN ; Aneesha Ahluwalia ; Caleb J. Murphy ; BS ; Ross F. Garberich ; MSc
• 关键词：Athletes ; Congenital heart disease ; Hypertrophic cardiomyopathy ; Sudden death
• 刊名：The American Journal of Medicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：129
• 期：11
• 页码：1170-1177
• 全文大小：522 K

文摘

Sudden deaths in young competitive athletes are tragic events, with high public visibility. The importance of race and gender with respect to sport and the diagnosis and causes of sudden death in athletes has generated substantial interest.

Methods

The US National Registry of Sudden Death in Athletes, 1980-2011, was accessed to define the epidemiology and causes of sudden deaths in competitive athletes. A total of 2406 deaths were identified in young athletes aged 19 ± 6 years engaged in 29 diverse sports.

Results

Among the 842 athletes with autopsy-confirmed cardiovascular diagnoses, the incidence in males exceeded that in females by 6.5-fold (1:121; 691 vs 1:787,392 athlete-years; P ≤.001). Hypertrophic cardiomyopathy was the single most common cause of sudden death, occurring in 302 of 842 athletes (36%) and accounting for 39% of male sudden deaths, almost 4-fold more common than among females (11%; P ≤.001). More frequent among females were congenital coronary artery anomalies (33% vs 17% of males; P ≤.001), arrhythmogenic right ventricular cardiomyopathy (13% vs 4%; P = .002), and clinically diagnosed long QT syndrome (7% vs 1.5%; P ≤.002). The cardiovascular death rate among African Americans/other minorities exceeded whites by almost 5-fold (1:12,778 vs 1:60; 746 athlete-years; P <.001), and hypertrophic cardiomyopathy was more common among African Americans/other minorities (42%) than in whites (31%; P ≤.001). Male and female basketball players were 3-fold more likely to be African American/other minorities than white.

Conclusions

Within this large forensic registry of competitive athletes, cardiovascular sudden deaths due to genetic and/or congenital heart diseases were uncommon in females and more common in African Americans/other minorities than in whites. Hypertrophic cardiomyopathy is an under-appreciated cause of sudden death in male minority athletes.