Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase
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- 作者：Dorota Pawlak ; Marta Schielmann ; Marek Wojciechowski ; Ryszard Andruszkiewicz
- 关键词：Glucosamine-6-phosphate synthase inhibitors ; Antifungal activity ; Synthesis
- 刊名：Bioorganic & Medicinal Chemistry Letters
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：26
- 期：15
- 页码：3586-3589
- 全文大小：848 K
文摘
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Novel esters derivatives of N3-4-metoxyfumaroyl-(S)-2,3-diaminopropanoic acid were synthesized.
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Antimicrobial and inhibition activity of new compounds were evaluated.
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Esters derivatives of FMDP with keto function display good anticandidal activity and inhibitory properties against glucosamine-6-phosphate synthase.
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Molecular modeling studies were performed.