PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining
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- 作者：Martijn S. Luijsterburg1 ; m.luijsterburg@lumc.nl" class="auth_mail" title="E-mail the corresponding author ; Inge de Krijger2 ; Wouter W. Wiegant1 ; Rashmi G. Shah3 ; Godelieve Smeenk1 ; Anton J.L. de Groot1 ; Alex Pines1 ; Alfred C.O. Vertegaal4 ; Jacqueline J.L. Jacobs2 ; Girish M. Shah3 ; Haico van Attikum1 ; h.van.attikum@lumc.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：18 February 2016
- 年：2016
- 卷：61
- 期：4
- 页码：547-562
- 全文大小：6732 K
文摘
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PARP1 recruits the chromatin remodeler CHD2 to DNA damage
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CHD2 promotes chromatin expansion and H3.3 deposition at DNA breaks
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CHD2 promotes the assembly of NHEJ repair complexes at DNA breaks
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PARP1 drives CHD2- and H3.3-dependent DNA repair by NHEJ