ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage
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- 作者：Cornelia G. Spruijt1 ; 2 ; 5 ; Martijn S. Luijsterburg3 ; 5 ; Roberta Menafra2 ; 6 ; Rik G.H. Lindeboom2 ; Pascal W.T.C. Jansen2 ; Raghu Ram Edupuganti2 ; Marijke P. Baltissen2 ; Wouter W. Wiegant3 ; Moritz C. Voelker-Albert1 ; 7 ; Filomena Matarese2 ; Anneloes Mensinga1 ; Ina Poser4 ; Harmjan R. Vos1 ; Hendrik G. Stunnenberg2 ; h.stunnenberg@ncmls.ru.nl" class="auth_mail" title="E-mail the corresponding author ; Haico van Attikum3 ; h.van.attikum@lumc.nl" class="auth_mail" title="E-mail the corresponding author ; Michiel Vermeulen2 ; 8 ; michiel.vermeulen@science.ru.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：NuRD ; ZMYND8 ; interaction proteomics ; next-generation sequencing ; gene expression ; DNA damage ; chromatin ; GATAD2A
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：17
- 期：3
- 页码：783-798
- 全文大小：16511 K
文摘
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ZMYND8 MYND domain interacts with PPPLФ motifs in NuRD subunit GATAD2A
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GATAD2A and GATAD2B define mutually exclusive NuRD subcomplexes
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ZMYND8 and NuRD co-localize on active (super)enhancers and promoters
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ZMYND8 recruits GATAD2A/NuRD to DNA breaks in a poly(ADP-ribose)-dependent manner