Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat
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- 作者：Vipin Arora&lowast ; ; Carlos Eduardo Morado-Urbina&lowast ; ; Carol A. Aschenbrenner&lowast ; ; Ken-ichiro Hayashida&lowast ; ; FuZhou Wang&lowast ; ; Thomas J. Martin&lowast ; ; James C. Eisenach&lowast ; ; &dagger ; ; Christopher M. Peters&lowast ; ; chrpeter@wfubmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Descending inhibition ; postoperative pain ; chronification ; glial plasticity ; growth curve
- 刊名：The Journal of Pain
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：17
- 期：2
- 页码：190-202
- 全文大小：3836 K
文摘
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Spinal noradrenergic signaling hastened resolution of hypersensitivity after plantar incision.
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Blockade of spinal noradrenergic signaling increased spinal glial activation after incision.
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Mixed growth curve analysis was used to model pain-related behaviors after plantar incision in the rat.