Direct oxidation of sugar nucleotides to the corresponding uronic acids: TEMPO and platinum-based procedures
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- 作者：Martin Rejzek ; Balaram Mukhopadhyay ; Cory Q. Wenzel ; Joseph S. Lam ; Robert A. Field
- 关键词：Sugar nucleotide ; Oxidation ; Uronic acid ; TEMPO ; Platinum
- 刊名：Carbohydrate Research
- 出版年：2007
- 出版时间：26 February 2007
- 年：2007
- 卷：342
- 期：3-4
- 页码：460-466
- 全文大小：257 K
文摘
The direct oxidation of UDP-α-d-glucose and UDP-N-acetyl-α-d-glucosamine to the corresponding uronic acids was explored using either TEMPO or platinum-catalysed oxidation with molecular oxygen. Whilst TEMPO-based procedures gave rise to substantial over-oxidation and/or degradation of UDP-glucose, oxidation of UDP-N-acetyl-glucosamine to UDP-N-acetyl-glucosaminuronic acid was achieved with >90 % conversion and ca. 65 % isolated yield using a platinum-catalysed procedure.