An expedient enzymatic route to isomeric 2-, 3- and 6-monodeoxy-monofluoro-maltose derivatives

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• 作者：Krit Tantanarat ; Martin Rejzek ; Ellis O¡¯Neill ; Christian Ruzanski ; Lionel Hill ; Shirley A. Fairhurst ; Tipaporn Limpaseni ; Robert A. Field
• 关键词：Fluoroglucose ; Glycogen ; trans-Glycosylation ; 19F NMR spectroscopy ; Fluoromaltose
• 刊名：Carbohydrate Research
• 出版年：2012
• 出版时间：1 September, 2012
• 年：2012
• 卷：358
• 期：Complete
• 页码：12-18
• 全文大小：518 K

文摘

2-Deoxy-2-fluoro-d-glucose, 3-deoxy-3-fluoro-d-glucose and 6-deoxy-6-fluoro-d-glucose were converted into the corresponding maltose derivatives using Arabidopsis thaliana DPE2-mediated trans-glycosylation reaction with glycogen acting as a glucosyl donor. ¹⁹F NMR spectroscopy proved to be a valuable tool for monitoring the progress of these reactions and to assess the nature of resulting oligomeric products.