Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate
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- 作者：Michelle A. Hughes1 ; Ian R. Powley1 ; Rebekah Jukes-Jones1 ; Sebastian Horn3 ; Maria Feoktistova4 ; Louise Fairall2 ; John W.R. Schwabe2 ; Martin Leverkus4 ; Kelvin Cain1 ; kc5@le.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Marion MacFarlane1 ; mm21@le.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 March 2016
- 年：2016
- 卷：61
- 期：6
- 页码：834-849
- 全文大小：4552 K
文摘
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c-FLIP isoforms (L/S) do not directly compete with caspase-8 for binding to FADD
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c-FLIP binds to the DISC via a co-operative hierarchical caspase-8-dependent process
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Co-operative and hierarchical binding crucially explains the dual function of c-FLIPL
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Our unified model defines how c-FLIP isoforms differentially direct cell fate