Store-Operated Ca2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity
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- 作者：Martin Vaeth1 ; Miriam Eckstein2 ; Patrick J. Shaw1 ; Lina Kozhaya3 ; 4 ; Jun Yang1 ; Friederike Berberich-Siebelt5 ; Robert Clancy6 ; Derya Unutmaz3 ; 4 ; Stefan Feske1 ; feskes01@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：STIM1 ; STIM2 ; SOCE ; CRAC channel ; calcium ; T follicular helper (Tfh) cells ; T follicular regulatory (Tfr) cells ; NFAT
- 刊名：Immunity
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：44
- 期：6
- 页码：1350-1364
- 全文大小：11877 K
文摘
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Dual role of SOCE in antibody-mediated protective immunity and autoimmunity
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SOCE regulates Tfr cell differentiation and prevents autoantibody production
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SOCE controls Tfh cell differentiation and production of pathogen-specific antibodies
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SOCE directs NFAT-mediated IRF4, BATF and Bcl-6 expression