Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction (PROTECT-ICD): Trial Protocol, Background and Significance

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• 作者：Sarah Zaman ; MBBS ; PhD^a ; ^b ; Andrew J. Taylor ; MBBS ; PhD^c ; ^d ; Martin Stiles ; MBChB ; PhD^e ; Clara Chow ; MBBS ; PhD^f ; ^g ; ^h ; Pramesh Kovoor ; MBBS ; PhD^f ; ^g ; ^{pramesh.kovoor@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sudden cardiac death ; Primary prevention ; Myocardial infarction ; Implantable-cardioverter defibrillator ; Randomised controlled trial
• 刊名：Heart, Lung and Circulation
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：25
• 期：11
• 页码：1055-1062
• 全文大小：1022 K

文摘

The ‘Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator Implantation to Prevent Tachyarrhythmias following Acute Myocardial Infarction’ (PROTECT-ICD) trial is an Australian-led multicentre randomised controlled trial targeting prevention of sudden cardiac death in patients who have at least moderately reduced cardiac function following a myocardial infarct (MI). The primary objective of the trial is to assess whether electrophysiological study to guide prophylactic implantation of an implantable cardioverter-defibrillator (ICD) early following MI (first 40 days) will lead to a significant reduction in sudden cardiac death and non-fatal arrhythmia. The secondary objective is to assess the utility of cardiac MRI (CMR) in assessing early myocardial characteristics, and its predictive value for both inducible ventricular tachycardia (VT) at EPS and SCD/ non-fatal arrhythmia at follow-up.